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Drug Name: Clomid AU
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Clomid AU

Active ingredient clomifene is a part of drug.

Pharmacology

Synthetic anti-estrogenic means. Blocks estrogenic receptors in a gipotalamo-pituitary system and peripheral fabrics. In this regard, in small doses has the stimulating impact on an inkretion of gonadotrophins, in high – anti-estrogenic action on ovaries.

On a feedback mechanism development of the gonadotrophins stimulating an ovulation amplifies.

After intake on an empty stomach it is completely absorbed in digestive tract. Is exposed to enterohepatic recirculation.

Metabolism in a liver.

The elimination half-life makes 5-7 days. Elimination with excrements and kidneys.

Clomifene application

Anovulatory infertility (induction of an ovulation), dysfunctional uterine bleedings, amenorrhea (a disgonadotropny form, secondary, post-contraceptive), a galactorrhoea (against the background of a hypophysis tumor), a polycystosis of ovaries (the Matte syndrome — Leventalya), Kiari-Frommel’s syndrome, androgenic insufficiency, an oligospermatism, for diagnostics of disturbances of gonadotropic function of a hypophysis.

Contraindications

Hypersensitivity, heavy liver and/or renal failure, uterine bleedings of not clear etiology, oothecoma, tumor or insufficiency of function of a hypophysis, pregnancy (including suspicion on it).

Use at pregnancy and feeding by a breast

Contraindicated at pregnancy.

Category of action on a fruit on FDA — X.

Side effects of the clomifene

The following symptoms are rare, but if you experience any of these, contact your doctor immediately:

• Blurred vision

• visual spots or flashes

• double vision

• Stomach or reduction in stomach pain

• Gastric edema

• weight gain

• shortness of breath

Prolonged use of clomiphene may increase the risk of ovarian cancer. Clomiphene should not be used for more than six cycles. Talk to your doctor about the risk of taking this medicine.

Clomiphene may cause other side effects. Call your doctor if you experience unusual problems while taking this medicine.

Interaction

Let’s combine with drugs of gonadotropic hormones.

Clomifene precautionary measures

Prior to the beginning of and during treatment constant observation of the gynecologist is necessary, it is necessary to check function of ovaries, to carry out vaginal examonations, to watch a phenomenon of “pupil”, etc. At increase in ovaries or their cystous transformation treatment by clomifene is stopped before normalization of the sizes of ovaries. Therapy is continued with use of the minimum doses or shorten the treatment period. Against the background of treatment it is recommended to control function of a liver. Persons whose professional activity demands fast physical and mental reactions cannot appoint without release from work.

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