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The semi-synthetic antibiotic of a penicillinic row amoxicillin is a part of drug. This substance is emitted from mushrooms and laboratory improved.

Action mechanism

Amoxicillin suppresses formation of a peptidoglikan, component of a cover of bacteria. The deficiency of this protein leads to destruction of a microorganism. The antibiotic possesses a broad spectrum of activity and is effective against:

• Causative agents of diseases of a respiratory system and ENT organs (staphylococcus, streptococci, hemophilic stick);

• Activator quinsy and pharyngitis (hemolitic streptococcus);

• Causative agent of gonorrhea (gonorrheal neysseriya);

• Contagiums of urinary tract and infections of the alimentary system (separate types of colibacillus).

Broad use of antibiotics and, in particular, penicillin derivatives, led to the fact that bacteria began to develop protection mechanisms. One of such is emergence in their structure of enzyme β-lactamelements which splits amoxicillin and similar to it on structure antibiotics before they work. Clavulanic acid suppresses activity of this enzyme, thereby enhancing efficiency of reception of antibiotics.

Indications

Amoksil is shown at the following states:

• Airways and ENT organs:

o Bronchitis.

o Pneumonia.

Angin’s o.

o Acute average otitis.

o Pharyngitis.

o Sinusitis.

• Urinogenital system:

o Urethritis.

o Cystitis.

o Pyelonephritis.

o Endometritis.

• Uncomplicated gonorrhea.

• Skin and soft tissues.

• GIT:

o Peritonitis.

o Coloenteritis.

o Cholecystitis.

o Cholangitis.

o Typhoid.

• Hay fever.

• Listeriosis.

• Meningitis.

• Lime disease (borreliosis).

• Prevention:

Endocarditis o.

o of the Surgical infection.

• Combination therapy:

Gastritis o.

o of the Peptic ulcer (in combination with metronidazole).

Sepsis o (together with aminoglycosides).

Contraindications

Amoxil it is impossible to apply at:

• Intolerance of drug, other penicillin or cephalosporins;

• Infectious mononucleosis.

Side effects

Amoxil can cause:

• Allergic reactions;

• Digestive disturbance;

• Heartbeat increase;

• Abnormal liver function or kidneys.

Inside.

To adults and teenagers 10 years – on 500-750 mg 2 times a day or 375-500 mg (up to 1 g are more senior at heavy infections) 3 times a day (the maximum daily dose – 6 g).

To children from 3 to 10 years – 375 mg 2 times or 250 mg 3 times a day, till 1 year – 125 mg 2 times or 100 mg 3 times a day. A daily dose for children – 30 mg/kg (up to 60 mg/kg), frequency rate of reception – 2-3 times.

At acute gonorrhea

3 g once in combination with 1 g of a probenetsid (repeated introduction is recommended to women).

To patients with creatinine Cl lower than 10 ml/min. reduce a dose by 15-50%, at an anury the dose should not exceed 2 g a day. An average course – 5-7 days (at streptococcal infections – not less than 10 days).

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